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News - High-dose vitamin D may help Crohn’s patients

By Nutri People

New research points to a potential role for vitamin D supplementation in people with Crohn’s disease – a serious inflammatory condition of the digestive system. The study, carried out by scientists at Weill-Cornell Medical College, sought to determine if high doses of vitamin-D3 supplementation in vitamin-D-deficient patients with Crohn’s disease leads to improved clinical outcomes.

Two groups of patients with Crohn’s disease, who had low vitamin D levels, were randomised to either low-dose (1,000 IU/day) or high-dose (10,000 IU/day) vitamin D treatment and assessed at day one, and after eight and 26 weeks of treatment. The investigators measured the patients’ symptom severity using a standard index.

The results showed that after 26 weeks of therapy, there were persistently significant differences in vitamin D levels between the high-dose and low-dose groups. What’s more, only the high-dose vitamin D group displayed significant changes in disease activity compared to the beginning of the study.

Commenting on their results the scientists wrote: “Our interim analysis suggests that supplementation with 10,000IU of vitamin D3 may be an effective adjunctive therapy for ameliorating symptoms in Crohn’s disease patients.”  

Article References

American College of Gastroenterology. High-dose Vitamin D3 Improves Clinical Activity in Crohn’s Disease. [Online] 2011.Available from http://gi.org/media/press-releases-for-acg-annual-scientific-meeting/ [Accessed November 7, 2011]

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