News - High-dose vitamin D may help Crohn’s patients
New research points to a potential role for vitamin D supplementation in people with Crohn’s disease – a serious inflammatory condition of the digestive system. The study, carried out by scientists at Weill-Cornell Medical College, sought to determine if high doses of vitamin-D3 supplementation in vitamin-D-deficient patients with Crohn’s disease leads to improved clinical outcomes.
Two groups of patients with Crohn’s disease, who had low vitamin D levels, were randomised to either low-dose (1,000 IU/day) or high-dose (10,000 IU/day) vitamin D treatment and assessed at day one, and after eight and 26 weeks of treatment. The investigators measured the patients’ symptom severity using a standard index.
The results showed that after 26 weeks of therapy, there were persistently significant differences in vitamin D levels between the high-dose and low-dose groups. What’s more, only the high-dose vitamin D group displayed significant changes in disease activity compared to the beginning of the study.
Commenting on their results the scientists wrote: “Our interim analysis suggests that supplementation with 10,000IU of vitamin D3 may be an effective adjunctive therapy for ameliorating symptoms in Crohn’s disease patients.”
American College of Gastroenterology. High-dose Vitamin D3 Improves Clinical Activity in Crohn’s Disease. [Online] 2011.Available from http://gi.org/media/press-releases-for-acg-annual-scientific-meeting/ [Accessed November 7, 2011]